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Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses

David Guerrero 1 Tineke Cantaert 1 Dorothée Missé 2, 3
2 MIVEGEC-iHAT - Interhuman Arbovirus Transmission
EDIFICE - Biologie des infections virales: Emergence, DIFfusion, Impact, Contrôle, Elimination
Abstract : Vector-borne diseases are responsible for over a billion infections each year and nearly one million deaths. Mosquito-borne dengue virus, West Nile, Japanese encephalitis, Zika, Chikungunya, and Rift Valley Fever viruses constitute major public health problems in regions with high densities of arthropod vectors. During the initial step of the transmission cycle, vector, host, and virus converge at the bite site, where local immune cells interactwith the vector’s saliva. Hematophagous mosquito saliva is a mixture of bioactive components known to modulate vertebrate hemostasis, immunity, and inflammation during the insect’s feeding process. The capacity of mosquito saliva to modulate the host immune response has been well-studied over the last few decades and has led to the consensus that the presence of saliva is linked to the enhancement of virus transmission, host susceptibility, disease progression, viremia levels, and mortality. We review some of the major aspects of the interactions between mosquito saliva and the host immune response that may be useful for future studies on the control of arboviruses.
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Soumis le : mercredi 7 octobre 2020 - 14:59:27
Dernière modification le : lundi 14 décembre 2020 - 17:30:29
Archivage à long terme le : : vendredi 8 janvier 2021 - 18:42:26


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David Guerrero, Tineke Cantaert, Dorothée Missé. Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses. Frontiers in Cellular and Infection Microbiology, Frontiers, 2020, 10, pp.407. ⟨10.3389/fcimb.2020.00407⟩. ⟨hal-02960009⟩



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