The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Biomaterials Science Année : 2020

The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

Morgane Daurat
  • Fonction : Auteur
Vincent Sol
Vincent Chaleix
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Khaled El Cheikh
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Michele Bernasconi
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Marcel Garcia
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Jochen Roessler
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Résumé

Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO–AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed
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Dates et versions

hal-02912281 , version 1 (26-11-2020)

Identifiants

Citer

Morgane Daurat, Christophe Nguyen, Sofia Dominguez Gil, Vincent Sol, Vincent Chaleix, et al.. The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics. Biomaterials Science, 2020, 8 (13), pp.3678-3684. ⟨10.1039/d0bm00586j⟩. ⟨hal-02912281⟩
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