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Article Dans Une Revue Journal of Autoimmunity Année : 2019

Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients

Résumé

Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4+ and CD8+ T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1*06:02-matched healthy controls. We detected a bias in the usage of TRAV3 and TRAV8 families, with public CDR3α motifs only present in CD4+ T cells from patients with NT1. These findings may offer a unique tool to identify disease-relevant antigens.
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Dates et versions

hal-02867986 , version 1 (22-10-2021)

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Paternité - Pas d'utilisation commerciale

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Eduardo Beltrán, Xuan-Hung Nguyen, Clémence Quériault, Lucie Barateau, Yves Dauvilliers, et al.. Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients. Journal of Autoimmunity, 2019, 100, pp.1-6. ⟨10.1016/j.jaut.2019.03.010⟩. ⟨hal-02867986⟩
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