Abnormal vaginal microbiome associated with vaginal mesh complications - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Neurourology and Urodynamics Année : 2019

Abnormal vaginal microbiome associated with vaginal mesh complications


Aims: To identify differences in the vaginal microbiomes of women after transvaginal mesh (TVM) surgery for pelvic organ prolapse with and without mesh-associated complications. Methods: Patients with complications were eligible as cases, patients without as controls. DNA was isolated and the V1-2 region of the 16S ribosomal RNA gene was amplified and sequenced. Overall richness was quantified using Chao1. Overall diversity was expressed as Shannon diversity and screened for group differences using analysis of variance. Multivariate differences among groups were evaluated with functions from R. Results: We recruited 14 patients after mesh exposure, 5 after contraction, and 21 as controls. The average number of operational taxonomic unit was 74.79 (SD ± 63.91) for controls, 57.13 (SD ± 58.74) after exposures, and 92.42 (SD ± 50.01) after contractions. Total 89.6% of bacteria in controls, 86.4% in previous exposures, and 81.3% in contractions were classified as either Firmicutes, Proteobacteria, or Actinobacteria (P < .001). Veillonella spp. was more abundant in patients after contraction (P = .045). The individual microbiomes varied, and we did not detect any significant differences in richness but a trend towards higher diversity with complications. Conclusions: The presence of Veillonella spp. could be associated with mesh contraction. Our study did not identify vaginal microbiotic dysbiosis as a factor associated with exposure. Larger cohort studies would be needed to distinguish the vaginal microbiome of women predisposed to mesh-related complications for targeted phenotyping of patients who could benefit from TVM surgery.
Fichier principal
Vignette du fichier
nau.24129.pdf (1.2 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02860317 , version 1 (08-06-2020)


Paternité - Pas d'utilisation commerciale



Nikolaus Veit-Rubinc, Renaud de Tayrac, Rufus Cartwright, Larissa Franklin-Revill, Sophie Warembourg, et al.. Abnormal vaginal microbiome associated with vaginal mesh complications. Neurourology and Urodynamics, 2019, 38 (8), pp.2255-2263. ⟨10.1002/nau.24129⟩. ⟨hal-02860317⟩
71 Consultations
79 Téléchargements



Gmail Facebook X LinkedIn More