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Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Haitham Mirghani 1, 2 Carine Bellera 3 Jessy Delaye 4 Gilles Dolivet 5 Nicolas Fakhry 6 Alexandre Bozec 7 Renaud Garrel 8 Olivier Malard 9, 10 Franck Jegoux 11 Philippe Maingon 12 Jérôme Sarini 13 Georges Noel 14 Suzy Duflo 15 Stéphane Temam 16 Jean-Louis Lefebvre 17 Valérie Costes-Martineau 18, 19 
Abstract : Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV) remains poorly investigated. Methods: we prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded. Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients' oncological outcomes. Conclusion: in France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.
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Soumis le : jeudi 4 juin 2020 - 12:27:20
Dernière modification le : vendredi 5 août 2022 - 10:42:08



Haitham Mirghani, Carine Bellera, Jessy Delaye, Gilles Dolivet, Nicolas Fakhry, et al.. Prevalence and characteristics of HPV-driven oropharyngeal cancer in France. Cancer Epidemiology, Elsevier, 2019, 61, pp.89-94. ⟨10.1016/j.canep.2019.05.007⟩. ⟨hal-02771653⟩



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