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Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

Ralf Kuja-Halkola 1 Joanna Martin 1, 2 Yi Lu 1 Christopher Hübel 3 Catarina Almqvist 1 Patrik Magnusson 4 Henrik Larsson 4 Roger Adan Tetsuya Ando Jessica Baker 5 Andrew Bergen 6 Wade Berrettini 7 Andreas Birgegård 8 Claudette Boni 9 Vesna Boraska Perica 10 Harry Brandt Roland Burghardt Matteo Cassina Carolyn Cesta Maurizio Clementi 11 Joni Coleman Roger Cone Philippe Courtet 12 Steven Crawford Scott Crow James Crowley 3 Unna Danner Oliver Davis Martina de Zwaan George Dedoussis 13 Daniela Degortes Janiece Desocio Danielle Dick Dimitris Dikeos 14 Monika Dmitrzak-Weglarz Elisa Docampo Karin Egberts Stefan Ehrlich 15 Geòrgia Escaramís Tonu Esko 16 Xavier Estivill 17 Angela Favaro Fernando Fernández-Aranda 18 Manfred Fichter Chris Finan Krista Fischer 19 Manuel Föcker Lenka Foretova 20 Monica Forzan Christopher Franklin Héléna Gaspar Fragiskos Gonidakis 21 Philip Gorwood 22 Mònica Gratacòs 17 Sébastien Guillaume 23 Yiran Guo Hakon Hakonarson 24 Katherine Halmi 25 Konstantinos Hatzikotoulas Joanna Hauser 26 Johannes Hebebrand 27 Sietske Helder Judith Hendriks Beate Herpertz-Dahlmann 28 Wolfgang Herzog Christopher Hilliard Anke Hinney 27 Laura Huckins 29 James Hudson 30 Julia Huemer Hartmut Imgart Hidetoshi Inoko 31 Susana Jiménez-Murcia 18 Craig Johnson 32 Jenny Jordan Anders Juréus Gursharan Kalsi Debora Kaminska Allan Kaplan Jaakko Kaprio 33 Leila Karhunen Andreas Karwautz 34 Martien Kas Walter Kaye 35 James Kennedy 36 Martin Kennedy 37 Anna Keski-Rahkonen 38 Kirsty Kiezebrink Youl-Ri Kim Kelly Klump Gun Peggy Knudsen Bobby Koeleman 39 Doris Koubek Maria La Via Mikael Landén 40 Robert Levitan Dong Li 41 Paul Lichtenstein 4 Lisa Lilenfeld Jolanta Lissowska 42 Pierre Magistretti 43 Mario Maj 44 Katrin Männik 45 Nicholas Martin 46 Sara Mcdevitt Peter Mcguffin 47 Elisabeth Merl Andres Metspalu 48 Ingrid Meulenbelt 49 Nadia Micali 50 James E Mitchell Karen Mitchell Palmiero Monteleone 51 Alessio Maria Monteleone Preben Mortensen Melissa Munn-Chernoff Benedetta Nacmias 52 Ida Nilsson Claes Norring 8 Ioanna Ntalla Julie O’toole Jacques Pantel 53 Hana Papezova 54 Richard Parker 55 Raquel Rabionet 17 Anu Raevuori 38 Andrzej Rajewski Nicolas Ramoz 22 N. William Rayner Ted Reichborn-Kjennerud 56 Valdo Ricca Stephan Ripke 57 Franziska Ritschel Marion Roberts Alessandro Rotondo Filip Rybakowski Paolo Santonastaso Andre Scherag 58 Ulrike Schmidt Nicholas Schork 59 Alexandra Schosser 60 Jochen Seitz Lenka Slachtova P. Eline Slagboom 61 Margarita Slof-Op’t Landt Agnieszka Slopien Tosha Smith Sandro Sorbi 52 Eric Strengman 26 Michael Strober 62 Patrick Sullivan 16 Jin Szatkiewicz 63 Neonila Szeszenia-Dabrowska 64 Ioanna Tachmazidou Elena Tenconi Laura Thornton 5 Alfonso Tortorella 65 Federica Tozzi 66 Janet Treasure Artemis Tsitsika Konstantinos Tziouvas Annemarie van Elburg 67 Eric van Furth Tracey Wade Gudrun Wagner 68 Esther Walton 69 Hunna Watson 5 D. Blake Woodside Shuyang Yao 4 Zeynep Yilmaz 70 Eleftheria Zeggini 71 Stephanie Zerwas Stephan Zipfel Lars Alfredsson 72 Ole Andreassen 73 Harald Aschauer Jeffrey Barrett 74 Vladimir Bencko 75 Laura Carlberg Sven Cichon 76 Sarah Cohen-Woods 60 Christian Dina 77 Bo Ding 78 Thomas Espeseth 79 James Floyd Steven Gallinger 80 Giovanni Gambaro Ina Giegling 16 Stefan Herms 81 Vladimir Janout 82 Antonio Julià 83 Lars Klareskog 84 Stephanie Le Hellard 85 Marion Leboyer 86 Astri Lundervold 85 Sara Marsal Morten Mattingsdal 73 Marie Navratilova 87 Roel Ophoff 88 Aarno Palotie 89 Dalila Pinto 90 Samuli Ripatti 1 Dan Rujescu 16 Stephen Scherer 90 Laura Scott 91 Robert Sladek 92 Nicole Soranzo 74 Lorraine Southam 71 Vidar Steen 85 H-Erich Wichmann 93 Elisabeth Widen 16 Gerome Breen 47 Cynthia Bulik 3, 4
68 SURFACES
IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon
Abstract : BACKGROUND: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. METHODS: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). RESULTS: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. CONCLUSIONS: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
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https://hal.umontpellier.fr/hal-02575225
Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : jeudi 14 mai 2020 - 16:58:42
Dernière modification le : mercredi 21 octobre 2020 - 17:02:02

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Ralf Kuja-Halkola, Joanna Martin, Yi Lu, Christopher Hübel, Catarina Almqvist, et al.. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry, Elsevier, 2019, 86 (8), pp.577-586. ⟨10.1016/j.biopsych.2019.04.036⟩. ⟨hal-02575225⟩

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