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Article dans une revue

Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment

Abstract : Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in distant parenchyma. Most of the CTCs released in the blood stream will not resist those challenges and will consequently fail to induce metastasis. A few of them, however, interact closely with other blood cells, such as neutrophils, platelets, and/or macrophages to survive in the blood stream. Recent studies demonstrated that the interaction and modulation of the blood microenvironment by CTCs is pivotal for the development of new metastasis, making it an interesting target for potential novel treatment strategies. This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies.
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https://hal.umontpellier.fr/hal-02571402
Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : mardi 12 mai 2020 - 18:47:49
Dernière modification le : mercredi 14 octobre 2020 - 04:22:21

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Simon Heeke, Baharia Mograbi, Catherine Alix-Panabières, Paul Hofman. Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment. Cells, MDPI, 2019, 8 (7), pp.714. ⟨10.3390/cells8070714⟩. ⟨hal-02571402⟩

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