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A Novel ALK–THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review

Abstract : Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm most frequently seen in the abdomino-pelvic region and lungs of children and young adults. Laryngeal tumors are rare. We present a case of a 23-year-old patient with a 5 month history of laryngitis and aphonia unresolved by corticotherapy. Laryngoscopy revealed a small, non-ulcerated, subepithelial, polypoid mass arising from the right vocal cord. The diagnosis of IMT with ALK expression was supported by histopathologic and molecular analysis. The THBS1 fusion partner was identified by RNA-sequencing analysis for the first time in a laryngeal IMT. This fusion partner has only been identified in six uterine IMTs thus far. Conservative excision of the lesion yielded excellent functional results for the patient. The voice was preserved and no recurrences were seen after 6 months of follow-up.
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https://hal.umontpellier.fr/hal-02569387
Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : lundi 11 mai 2020 - 12:04:29
Dernière modification le : lundi 20 juillet 2020 - 18:46:02

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Abderrahim Elktaibi, Nazim Benzerdjeb, Fatima Ameur, Clementine Daveau, Juliet Tantot, et al.. A Novel ALK–THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. Head and Neck Pathology, 2019, ⟨10.1007/s12105-019-01061-x⟩. ⟨hal-02569387⟩

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