Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Communications Biology Année : 2019

Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions

Hubert Taillades
  • Fonction : Auteur
  • PersonId : 902028

Résumé

Intrauterine adhesions lead to partial or complete obliteration of the uterine cavity and have life-changing consequences for women. The leading cause of adhesions is believed to be loss of stroma resulting from trauma to the endometrium after surgery. Adhesions are formed when lost stroma is replaced by fibrous tissue that join the uterine walls. Few effective intrauterine anti-adhesion barriers for gynecological surgery exist. We designed a degradable anti-adhesion medical device prototype to prevent adhesion formation and recurrence and restore uterine morphology. We focused on ideal degradation time for complete uterine re-epithelialization for optimal anti-adhesion effect and clinical usability. We developed a triblock copolymer prototype [poly(lactide) combined with high molecular mass poly(ethylene oxide)]. Comparative pre-clinical studies demonstrated in vivo anti-adhesion efficacy. Ease of introduction and optimal deployment in a human uterus confirmed clinical usability. This article provides preliminary data to develop an intrauterine medical device and conduct a clinical trial.
Fichier principal
Vignette du fichier
42003_2019_Article_447.pdf (5.21 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02555379 , version 1 (27-04-2020)

Identifiants

Citer

Salomé Leprince, Stéphanie Huberlant, Lucie Allègre, Sophie Warembourg, Isabelle Leteuff, et al.. Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions. Communications Biology, 2019, 2 (1), ⟨10.1038/s42003-019-0447-x⟩. ⟨hal-02555379⟩
39 Consultations
67 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More