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Blood pressure profile and endothelial function in restless legs syndrome

Abstract : Restless legs syndrome (RLS) is frequently comorbid with hypertension and cardiovascular diseases; however this relationship and underlying mechanisms remain controversial. After clinical evaluation, 84 drug-free patients with primary RLS (53 women; mean age 55.1 ± 12.3 years) and 76 controls (47 women; mean age 52.2 ± 15.3 years) underwent 24-hour ambulatory blood pressure (BP) and polysomnographic monitoring, and peripheral arterial tonometry to assess endothelial function for 61 patients and 69 controls. Hypertension was diagnosed in 11.9% of patients with RLS based on office measurement, and in 46.4% on the 24 h recording, with nighttime hypertension, two times more frequent than daytime hypertension. Periodic limb movement during sleep (PLMS), markers of sleep fragmentation, and systolic and mean BP non-dipping profile were more frequent among patients. BP non-dipping status was associated with older age, later RLS onset and diagnosis, RLS severity and higher sleep fragmentation. The mean 24-hour, daytime and nighttime BP values, the frequency of hypertension and the endothelial function were comparable between groups. However, both systolic and diastolic BP trajectories over a 24-hour period differed between groups. In conclusion, patients with RLS exhibit a 24-hour BP deregulation with increased frequency of systolic non-dipping profiles that could worsen the risk for CVD morbidity and mortality.
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Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : vendredi 17 avril 2020 - 11:02:00
Dernière modification le : vendredi 15 mai 2020 - 12:22:09

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Sofiene Chenini, Anna Laura Rassu, Lily Guiraud, Elisa Evangelista, Lucie Barateau, et al.. Blood pressure profile and endothelial function in restless legs syndrome. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52401-4⟩. ⟨hal-02545540⟩



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