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Partial acute transverse myelitis is a predictor of multiple sclerosis in children

Abstract : Background: Acute transverse myelitis (ATM) in children is a rare and often severe disease for which there are few known prognostic factors, particularly the subsequent risk of multiple sclerosis (MS) diagnosis. Objectives: To determine the clinical course and prognostic factors after a first episode of ATM in children. Methods: Thirty children below 16 years of age diagnosed with a first neurological episode of ATM were included retrospectively. Clinical evaluation, treatment, laboratory, and MRI data were collected. Results: Median age at onset was 11 years (range 3-15 years). Follow-up data were available for a median of 4 years (range 0.5-16.7 years). Five patients subsequently had a diagnosis of MS (17%), which was associated with acute partial transverse myelitis (odds ratio 5; 95% confidence interval 2.3-11), with a 60% probability of having a relapse at five years (p < 0.01). The 2011 Verhey criteria correctly identified MS in children with the highest specificity (96%) and sensitivity (80%). Conclusion: Acute partial transverse myelitis and brain MRI abnormalities at initial presentation are significantly predictive of a subsequent diagnosis of MS in children with ATM. These findings suggest that closer brain MRI monitoring after acute partial transverse myelitis might make the earlier introduction of disease-modifying therapies possible.
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Soumis le : jeudi 16 avril 2020 - 14:59:12
Dernière modification le : jeudi 28 mai 2020 - 03:32:46


Meyer et al - 2014.pdf
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Pierre Meyer, N. Leboucq, N. Molinari, A. Roubertie, M. Carneiro, et al.. Partial acute transverse myelitis is a predictor of multiple sclerosis in children. Multiple Sclerosis Journal, SAGE Publications, 2014, 20 (11), pp.1485-1493. ⟨10.1177/1352458514526943⟩. ⟨hal-02544667⟩



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