Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Gene Expression Patterns Année : 2013

Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development

Résumé

Regulation of the Bone Morphogenetic Protein (BMP) signaling pathway is essential for the normal development of vertebrate gastrointestinal (GI) tract, but also for the differentiation of the digestive mesen-chymal layer into smooth muscles and submucosal layer. Different studies demonstrated that Bapx1 (for bagpipe homeobox homolog 1) negatively regulates the BMP pathway, but its precise expression pattern during the development and the differentiation of the GI tract mesenchyme actually remains to be examined. Here, we present the spatio-temporal expression profile of Bapx1 in the chick GI tract. We show that Bapx1 is first expressed in the undifferentiated mesenchyme of the gizzard and the colon. After the differentiation of the digestive mesenchyme, we found Bapx1 strongly expressed in the gizzard smooth muscle and in the submucosa layer of the colon. This expression pattern provides new insights into the roles of Bapx1 during the regionalization of the GI tract and the differentiation of the digestive mesenchyme of the colon and the stomach.
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Dates et versions

hal-02543674 , version 1 (15-04-2020)

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Sandrine Faure, Maxime Georges, Jennifer Mckey, Sébastien Sagnol, Pascal de Santa Barbara. Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development. Gene Expression Patterns, 2013, ⟨10.1016/j.gep.2013.05.005⟩. ⟨hal-02543674⟩
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