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Polyphenols prevent lipid abnormalities and arterial dysfunction in hamsters on a high-fat diet: a comparative study of red grape and white persimmon wines

Abstract : Scope: We compared the effects of two dealcoholized wines, persimmon (P) and Merlot (M), in hypercholesterolemic hamsters. Methods and results: Four groups of hamsters received a standard (ST) or an atherogenic diet (AT) for 12 weeks. AT animals received either dealcoholized persimmon wine (AT + P) or Merlot wine (AT + M) by gavage, while controls received water (AT and ST). Plasma cholesterol, triglycerides and glucose and paraoxonase activity were measured. Oxidative stress was assessed by aortic O(2)°(-) production, and vascular function was evaluated in aortic rings. The atherogenic diet led to higher plasma triglycerides (246%), total cholesterol (142%), LDL-cholesterol (91%) and HDL-cholesterol (49%). Aortic production of O(2)°(-) also increased (207%) and vascular reactivity was modified with altered endothelial function as assessed by acetylcholine-dependent vasorelaxation. The two wines partially prevented these alterations, reducing O(2)°(-) production and improving vascular reactivity without altering endothelial function. There was no difference between the P and M groups, although the procyanidin composition of the two dealcoholized fractions differed significantly, and only dimer concentrations were similar. Conclusion: These findings indicate that polyphenols are responsible, at least in part, for the antiatherogenic/antioxidant effects of wines.
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https://hal.umontpellier.fr/hal-02542519
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Soumis le : mercredi 15 avril 2020 - 11:58:08
Dernière modification le : vendredi 29 mai 2020 - 03:33:39

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Jin-Hyang Suh, Anne Virsolvy, Aurélie Goux, Cécile Cassan, Sylvain Richard, et al.. Polyphenols prevent lipid abnormalities and arterial dysfunction in hamsters on a high-fat diet: a comparative study of red grape and white persimmon wines. Food and Function, Cambridge : Royal Society of Chemistry, 2011, 2 (9), pp.555. ⟨10.1039/c1fo10066a⟩. ⟨hal-02542519⟩

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