Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism

Abstract : Background and aims: Maternal obesity and post-natal over-nutrition play an important role in programming glucose and lipid metabolism later in life. The aim of this study was to decipher the contributions of maternal obesity and post-natal over-nutrition on glucose and lipid metabolism in skeletal muscle. Method and results: Male offspring of Sprague Dawley rat mothers fed either chow or high fat diet (HFD) for 5 weeks prior to mating were subsequently fed either chow or HFD until 18 weeks of age. Collection of plasma and skeletal muscle was performed at weaning (20 days) and 18 weeks. At weaning, offspring from obese mothers showed increased body weight, plasma insulin and lactate concentrations associated with reduced skeletal muscle glucose transporter 4 (GLUT4) and increased monocarboxylate transporter 1 (MCT1) protein. In 18-week old offspring, post-weaning HFD further exacerbated the elevated body weight caused by maternal obesity. Surprisingly this additive effect on body weight was not reflected in plasma glucose, insulin, lactate and MCT1; these markers were only increased by post-weaning HFD consumption. However, an additive effect of maternal obesity and post-weaning HFD led to decreased muscle GLUT4 levels, as well as mRNA levels of carnitine palmitoyl trans-ferase-1, myogenic differentiation protein and myogenin. Conclusion: Post-weaning HFD exerted an additive effect to that of maternal obesity on body weight and skeletal muscle markers of glucose and lipid metabolism but not on plasma glucose and insulin levels, suggesting that maternal obesity and post-natal over-nutrition impair skeletal muscle function via different mechanisms. ª
Liste complète des métadonnées

Littérature citée [36 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02540646
Contributeur : Emilie Passerieux <>
Soumis le : samedi 11 avril 2020 - 15:36:17
Dernière modification le : vendredi 15 mai 2020 - 12:22:09

Fichier

Simar et al - 2012.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

D. Simar, H. Chen, Karen Lambert, Jacques Mercier, M Morris. Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism. Nutrition, Metabolism and Cardiovascular Diseases, Elsevier, 2012, 22 (3), pp.269-276. ⟨10.1016/j.numecd.2010.11.007⟩. ⟨hal-02540646⟩

Partager

Métriques

Consultations de la notice

28

Téléchargements de fichiers

30