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Herpes simplex virus type 2 and cancer: A medical geography approach

Abstract : Herpes simplex virus type-2 (HSV-2) has been identified as a possible aetiological agent of cancer in humans, especially prostate cancer, but results remain controversial. Here, we have addressed this question using a medical geography approach based on the national incidence of various cancers and seroprevalence of HSV-2 in 64 countries worldwide. We corrected reports of cancer incidence for national gross domestic product (GDP) because living in a wealthy nation likely increases the probability of having a cancer detected. Data were also corrected for latitude and diet. Our analysis not only confirms that prostate cancer and HSV-2 seroprevalence are positively associated, but it also reveals the existence of a positive relationship between HSV-2 and melanoma incidence in both men and women. These results, though correlational, suggest that HSV-2 should continue to be investigated as a possible oncogenic pathogen of humans.
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Soumis le : mercredi 18 mars 2020 - 16:23:15
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Fréderic Thomas, Eric Elguero, Jacques Brodeur, Jérôme Le Goff, Dorothée Missé. Herpes simplex virus type 2 and cancer: A medical geography approach. Infection, Genetics and Evolution, Elsevier, 2011, 11 (6), pp.1239-1242. ⟨10.1016/j.meegid.2011.04.009⟩. ⟨hal-02511283⟩



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