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Determinants of life-history traits in a fish ectoparasite: a hierarchical analysis

Abstract : BACKGROUND: Proteomic analysis was performed to identify proteins regulated during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line. The potential of these viruses to cause severe disease at primary infection is of interest although few studies have been performed with these two Dengue serotypes. RESULTS: The most relevant observation of our study is the significant overexpression of proteins involved in the cellular stress response and the glycolysis pathway after 48 hours of infection. Viral infection activates the translation of some host genes, which may result in stress due to responses involving unfolded proteins. CONCLUSIONS: Therefore, the oxidation reduction and glycolytic mechanisms could participate in the antiviral response against Dengue virus. The results of our study should help to improve our knowledge of the virus-mosquito interaction at a cellular level with the aim of designing efficient strategies for the control of Dengue virus.
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Soumis le : mercredi 18 mars 2020 - 16:15:29
Dernière modification le : jeudi 19 mars 2020 - 01:32:02

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G. Loot, N. Poulet, S. Brosse, L. Tudesque, S. Blanchet, et al.. Determinants of life-history traits in a fish ectoparasite: a hierarchical analysis. Parasitology, Cambridge University Press (CUP), 2011, 138 (7), pp.848-857. ⟨10.1017/S003118201100014X⟩. ⟨hal-02511262⟩



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