Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice

Abstract : MLC901, a traditional Chinese medicine containing a cocktail of active molecules, both reduces cerebral infarction and improves recovery in patients with ischemic stroke. The aim of this study was to evaluate the acute and long-term benefits of MLC901 in ischemic and reperfused mouse hearts. Ex vivo, under physiological conditions, MLC901 did not show any modification in heart rate and contraction amplitude. However, upon an ischemic insult, MLC901 administration during reperfusion, improved coronary flow in perfused hearts. In vivo, MLC901 (4 µg/kg) intravenous injection 5 minutes before reperfusion provided a decrease in both infarct size (49.8%) and apoptosis (49.9%) after 1 hour of reperfusion. Akt and ERK1/2 survival pathways were significantly activated in the myocardium of those mice. In the 4-month clinical follow-up upon an additional continuous per os administration, MLC901 treatment decreased cardiac injury as revealed by a 45%-decrease in cTnI plasmatic concentrations and an improved cardiac performance assessed by echocardiography. A histological analysis revealed a 64%-decreased residual scar fibrosis and a 44%-increased vascular density in the infarct region. This paper demonstrates that MLC901 treatment was able to provide acute and long-term cardioprotective effects in a murine model of myocardial ischemia-reperfusion injury in vivo.
Liste complète des métadonnées

https://hal.umontpellier.fr/hal-02506308
Contributeur : Anne Vincent <>
Soumis le : jeudi 12 mars 2020 - 11:38:18
Dernière modification le : vendredi 13 mars 2020 - 01:44:12

Lien texte intégral

Identifiants

Citation

Anne Vincent, Aurélie Covinhes, Christian Barrère, Laura Gallot, Soulit Thoumala, et al.. Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice. Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-14822-x⟩. ⟨hal-02506308⟩

Partager

Métriques

Consultations de la notice

35