Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Evolutionary Applications Année : 2013

Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations

Résumé

If the occurrence of cancer is the result of a random lottery among cells, then body mass, a surrogate for cells number, should predict cancer incidence. Despite some support in humans, this assertion does not hold over the range of different natural animal species where cancer incidence is known. Explaining the so-called 'Peto's paradox' is likely to increase our understanding of how cancer defense mechanisms are shaped by natural selection. Here, we study how body mass may affect the evolutionary dynamics of tumor suppressor gene (TSG) inactivation and oncogene activation in natural animal species. We show that the rate of TSG inactivation should evolve to lower values along a gradient of body mass in a nonlinear manner, having a threshold beyond which benefits to adaptive traits cannot overcome their costs. We also show that oncogenes may be frequently activated within populations of large organisms. We then propose experimental settings that can be employed to identify protection mechanisms against cancer. We finally highlight fundamental species traits that natural selection should favor against carcinogenesis. We conclude on the necessity of comparing genomes between populations of a single species or genomes between species to better understand how evolution has molded protective mechanisms against cancer development and associated mortality.
Fichier principal
Vignette du fichier
Thomas_39.pdf (361.43 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02504064 , version 1 (10-03-2020)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Benjamin Roche, Kathleen Sprouffske, Hassan Hbid, Dorothée Missé, Frédéric Thomas. Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations. Evolutionary Applications, 2013, 6 (1), pp.109-116. ⟨10.1111/eva.12025⟩. ⟨hal-02504064⟩
47 Consultations
63 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More