Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine

Abstract : For an increasing number of biologists, cancer is viewed as a dynamic system governed by evolutionary and ecological principles. Throughout most of human history, cancer was an uncommon cause of death and it is generally accepted that common components of modern culture, including increased physiological stresses and caloric intake, favor cancer development. However, the precise mechanisms for this linkage are not well understood. Here, we examine the roles of ecological and physiological disturbances and resource availability on the emergence of cancer in multicellular organisms. We argue that proliferation of 'profiteering phenotypes' is often an emergent property of disturbed, resource-rich environments at all scales of biological organization. We review the evidence for this phenomenon, explore it within the context of malignancy, and discuss how this ecological framework may offer a theoretical background for novel strategies of cancer prevention. This work provides a compelling argument that the traditional separation between medicine and evolutionary ecology remains a fundamental limitation that needs to be overcome if complex processes, such as oncogenesis, are to be completely understood.
Liste complète des métadonnées

Littérature citée [116 références]  Voir  Masquer  Télécharger
Contributeur : Anthony Herrada <>
Soumis le : mercredi 11 mars 2020 - 11:54:03
Dernière modification le : samedi 14 mars 2020 - 01:32:29


Fichiers éditeurs autorisés sur une archive ouverte


Distributed under a Creative Commons Paternité 4.0 International License



Hugo Ducasse, Audrey Arnal, Marion Vittecoq, Simon Daoust, Beata Ujvari, et al.. Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine. Evolutionary Applications, Blackwell, 2015, 8 (6), pp.527-540. ⟨10.1111/eva.12232⟩. ⟨hal-02502838⟩



Consultations de la notice


Téléchargements de fichiers