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Rare and unique adaptations to cancer in domesticated species: An untapped resource?

Frederic Thomas 1 Mathieu Giraudeau 1 Nolwenn M Dheilly 2 Flora Gouzerh 1 Justine Boutry 1 Christa Beckmann 3, 4 Peter A. Biro 3 Rodrigo Hamede 5 Jerome Abadie 6 Sophie Labrut 6 Margaux Bieuville 1 Dorothée Missé 1 Georgina Bramwell 3 Aaron Schultz 3 Guillaume Le Loc'H 7 Orsolya Vincze 8, 9, 10 Benjamin Roche 1, 11 François Renaud 1 Tracey Russell 12 Beata Ujvari 3, 5
1 MIVEGEC-CREEC - Centre de Recherches Ecologiques et Evolutives sur le Cancer
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
2 SoMAS - School of Marine and Atmospheric Sciences [Stony Brook]
3 Deakin University, Burwood, Australia
4 UWS - Western Sydney University
5 UTAS - University of Tasmania [Hobart, Australia]
6 AMaROC - Animaux modèles pour la recherche en oncologie comparée
ONIRIS - Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique
7 IHAP - Interactions hôtes-agents pathogènes [Toulouse]
8 Hungarian Department of Biology and Ecology [Cluj‑Napoca, Romania]
9 UBB - Babes-Bolyai University [Cluj-Napoca]
10 MTA Centre for Ecological Research [Tihany]
11 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
12 The University of Sydney
Abstract : Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti‐cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the “domestication” of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found.
Keywords : evolutionary mismatch selection cancer domestication domestication syndrome evolution
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UNIV-MONTPELLIER | AGROPOLIS | IRD | B3ESTE | SORBONNE-UNIVERSITE | UMI-209 | CNRS | SU-SCIENCES | INRAE | SU-TI | UNAM

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Frederic Thomas, Mathieu Giraudeau, Nolwenn M Dheilly, Flora Gouzerh, Justine Boutry, et al.. Rare and unique adaptations to cancer in domesticated species: An untapped resource?. Evolutionary Applications, Blackwell, 2020, 13 (7), pp.1605-1614. ⟨10.1111/eva.12920⟩. ⟨hal-02469220⟩

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