1,3-Dihydrobenzo[ c ]furan nucleoside analogues: additional studies of the thymine derivative

Abstract : The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5'-triphosphate derivative to interact efficiently with the reverse transcriptase.
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https://hal.umontpellier.fr/hal-02433976
Contributeur : Monique Hibade <>
Soumis le : jeudi 9 janvier 2020 - 16:00:14
Dernière modification le : vendredi 10 janvier 2020 - 16:10:03

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David Egron, Christian Perigaud, Gilles Gosselin, Anne-Marie Aubertin, Abdesslem Faraj, et al.. 1,3-Dihydrobenzo[ c ]furan nucleoside analogues: additional studies of the thymine derivative. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2003, 13 (24), pp.4473-4475. ⟨10.1016/j.bmcl.2003.09.031⟩. ⟨hal-02433976⟩

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