Electrical stimulation of the dorsolateral prefrontal cortex impairs semantic cognition

Abstract : OBJECTIVE: To identify the prefrontal cortical structures causally involved in verbal and nonverbal semantic cognition in both cerebral hemispheres. METHODS: We retrospectively screened the intraoperative brain mapping data of 584 patients who underwent neurosurgery for neoplastic tumor under local anesthesia with direct cortical electrostimulation. Patients were included if they were right-handed, recently diagnosed with a diffuse low-grade glioma, and had a positive language mapping for verbal (naming task) and nonverbal (visual semantic association task) semantic cognition in the prefrontal cortex (n = 49). Among these, 30 were tested intraoperatively with both the naming and the semantic association tasks, while 19 were tested with the naming task only. Subsequently, each semantic site (n = 85) was plotted individually onto a common stereotaxic space for detailed analyses. RESULTS: The cortical sites associated with verbal semantic disturbances (n = 45) were distributed in the pars opercularis (n = 14) and pars triangularis (n = 19) of the left inferior frontal gyrus, and left dorsolateral prefrontal cortex (dlPFC, n = 12); only 2 sites were observed in the right dlPFC. In contrast, all but one cortical site associated with nonverbal semantic disturbances were observed in the left dorsolateral cortex (n = 8). In the right hemisphere, the same disturbances were found in the dlPFC (n = 14) and pars opercularis (n = 2). CONCLUSION: The present study demonstrated the critical role of the dlPFC in the semantic network, and indicated its specific and bilateral involvement in nonverbal semantic cognition in right-handers.
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https://hal.umontpellier.fr/hal-02387057
Contributeur : Cécile Nowak <>
Soumis le : vendredi 29 novembre 2019 - 15:36:02
Dernière modification le : samedi 30 novembre 2019 - 01:26:01

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Guillaume Herbet, Sylvie Moritz-Gasser, Hugues Duffau. Electrical stimulation of the dorsolateral prefrontal cortex impairs semantic cognition. Neurology, 2018, 90 (12), pp.e1077--e1084. ⟨10.1212/WNL.0000000000005174⟩. ⟨hal-02387057⟩

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