RIP140 and LCoR expression in gastrointestinal cancers - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Oncotarget Année : 2017

RIP140 and LCoR expression in gastrointestinal cancers

Résumé

The transcription coregulators RIP140 and LCoR are part of a same complex which controls the activity of various transcription factors and cancer cell proliferation. In this study, we have investigated the expression of these two genes in human colorectal and gastric cancers by immunohistochemistry. In both types of tumors, the levels of RIP140 and LCoR appeared highly correlated. Their expression tended to decrease in colorectal cancer as compared to adjacent normal tissues but was found higher in gastric cancer as compared to normal stomach. RIP140 and LCoR expression correlated with TNM and tumor differentiation. Significant correlations were observed with expression levels of key proteins involved in tumor progression and invasion namely E-cadherin and Cyclooxygenase-2. Survival analysis showed that patients with LCoRlow/RIP140high colorectal tumors have a significant prolonged overall and disease-free survival. In gastric cancer, high LCoR expression was identified as an independent marker of poor prognosis suggesting a key role in this malignancy. Altogether, these results demonstrate that RIP140 and LCoR have a prognostic relevance in gastrointestinal cancers and could represent new potential biomarkers in these tumors.
Fichier principal
Vignette du fichier
22686-320351-5-PB.pdf (3.1 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02370376 , version 1 (08-06-2021)

Licence

Paternité

Identifiants

Citer

Mouna Triki, Dorra Ben Ayed-Guerfali, Ines Saguem, Slim Charfi, Lobna Ayedi, et al.. RIP140 and LCoR expression in gastrointestinal cancers. Oncotarget, 2017, 8 (67), pp.111161-111175. ⟨10.18632/oncotarget.22686⟩. ⟨hal-02370376⟩
43 Consultations
41 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More