Prevalence and determinants of HIV shedding in breast milk during continued breastfeeding among Zambian mothers not on antiretroviral treatment (ART) - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Medicine Année : 2019

Prevalence and determinants of HIV shedding in breast milk during continued breastfeeding among Zambian mothers not on antiretroviral treatment (ART)

Résumé

The risk of postnatal HIV transmission exists throughout the breastfeeding period. HIV shedding in breast milk beyond six months has not been studied extensively. The aim of this study was to determine prevalence and determinants of HIV shedding in breast milk during continued breastfeeding A cross-sectional study was nested in the PROMISE-PEP trial in Lusaka, Zambia to analyze breast milk samples collected from both breasts at week 38 post-partum (mid-way during continued breastfeeding). We measured concurrent HIV deoxyribonucleic acid (DNA) and HIV ribonucleic acid (RNA) as proxies for cell-associated HIV (CAV) and cell-free HIV (CFV) shedding in breast milk respectively. Participants' socio-demographic date, concurrent blood test results, sub clinical mastitis test results and contraceptive use data were available. Logistic regression models were used to identify determinants of HIV shedding in breast milk (detecting either CAV or CFV). The prevalence of HIV shedding in breast milk at 9 months post-partum was 79.4% (95%CI: 74.0-84.0). CAV only, CFV only and both CAV and CFV were detectable in 13.7%, 17.3% and 48.4% mothers, respectively. The odds of shedding HIV in breast milk decreased significantly with current use of combined oral contraceptives (AOR: 0.37; 95%CI: 0.17-0.83) and increased significantly with low CD4 count (AOR: 3.47; 95%CI: 1.23-9.80), unsuppressed plasma viral load (AOR: 6.27; 95%CI: 2.47-15.96) and severe sub-clinical mastitis (AOR: 12.56; 95%CI: 2.48-63.58). This study estimated that about 80% of HIV infected mothers not on ART shed HIV in breast milk during continued breastfeeding. Major factors driving this shedding were low CD4 count, unsuppressed plasma viral load and severe sub-clinical mastitis. The inverse relationship between breast milk HIV and use of combined oral contraceptives needs further clarification. Continued shedding of CAV may contribute to residual postnatal transmission of HIV in mothers on successful ART.
Fichier principal
Vignette du fichier
Prevalence_and_determinants_of_HIV_shedding.pdf (211.26 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02368127 , version 1 (06-11-2020)

Licence

Paternité

Identifiants

Citer

David Gatsinzi Rutagwera, Jean-Pierre Molès, Chipepo Kankasa, Mwiya Mwiya, Edouard Tuaillon, et al.. Prevalence and determinants of HIV shedding in breast milk during continued breastfeeding among Zambian mothers not on antiretroviral treatment (ART). Medicine, 2019, 98 (44), pp.e17383. ⟨10.1097/md.0000000000017383⟩. ⟨hal-02368127⟩
74 Consultations
85 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More