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Article Dans Une Revue RSC Advances Année : 2019

Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA

Résumé

Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to “bare” porous silicon nanoparticles.

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Chimie
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hal-02338857 , version 1 (31-05-2021)

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Arnaud Chaix, Eduardo Cueto-Diaz, Anthony Delalande, Nikola Knezevic, Patrick Midoux, et al.. Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA. RSC Advances, 2019, 9 (55), pp.31895-31899. ⟨10.1039/c9ra05461h⟩. ⟨hal-02338857⟩
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