RANIBIZUMAB AND AFLIBERCEPT FOR THE TREATMENT OF PIGMENT EPITHELIAL DETACHMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue RETINA. The Journal of Retinal and Vitreous Diseases Année : 2018

RANIBIZUMAB AND AFLIBERCEPT FOR THE TREATMENT OF PIGMENT EPITHELIAL DETACHMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Anagha Vaze
  • Fonction : Auteur
Vuong Quoc Nguyen
  • Fonction : Auteur
Jennifer Arnold
  • Fonction : Auteur
Stephanie Young
  • Fonction : Auteur
Chui Cheung
  • Fonction : Auteur
Ecosse Lamoureux
  • Fonction : Auteur
Mayuri Bhargava
  • Fonction : Auteur
Daniel Barthelmes
  • Fonction : Auteur
Mark Gillies
  • Fonction : Auteur

Résumé

PURPOSE: To assess the effect of intravitreal ranibizumab and aflibercept on retinal pigment epithelial detachment (RPED) in patients with neovascular age-related macular degeneration. METHODS: This was a retrospective analysis of data from a prospectively designed and implemented clinical audit. Analysis included change in RPED dimensions and visual acuity in 92/233 treatment-naive eyes with neovascular age-related macular degeneration and RPED 6 months after treatment with either aflibercept or ranibizumab. RESULTS: There was no significant between-group difference in the adjusted mean change for maximum RPED height (P = 0.195), diameter (P = 0.522) or visual acuity (P = 0.836) at 6 months. Injection frequency was the only clinical variable that affected RPED height (P = 0.050) and visual acuity change for both treatment groups (P = 0.004). Around 30% of eyes in each group had complete resolution of RPED at 6 months. CONCLUSION: Eyes with neovascular age-related macular degeneration and RPED showed significant functional and anatomical responses after 6 months of intravitreal anti-vascular endothelial growth factor injections. However, we found no significant difference in anatomical response or change in visual acuity between eyes treated with ranibizumab compared with aflibercept. Larger, prospectively designed, randomized studies with longer term follow-up may identify a difference between the two drugs that we did not detect.

Dates et versions

hal-02337323 , version 1 (29-10-2019)

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Citer

Anagha Vaze, Vuong Quoc Nguyen, Vincent Daien, Jennifer Arnold, Stephanie Young, et al.. RANIBIZUMAB AND AFLIBERCEPT FOR THE TREATMENT OF PIGMENT EPITHELIAL DETACHMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. RETINA. The Journal of Retinal and Vitreous Diseases, 2018, 38 (10), pp.1954-1961. ⟨10.1097/IAE.0000000000001815⟩. ⟨hal-02337323⟩
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