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Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)

A. Bonaventure 1, 2, 3 L. Orsi 1 J. Rudant 1, 2 S. Goujon-Bellec 1, 2 G. Leverger 4 A. Baruchel 5 Y. Bertrand 6 B. Nelken 7 M. Pasquet 8 G. Michel 9 N. Sirvent 10, 11 P. Chastagner 12 S. Ducassou 13 C. Thomas 14 C. Besse 15 D. Hemon 1 J. Clavel 1, 2
1 CRESS - U1153 - Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent
UPD5 - Université Paris Descartes - Paris 5, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
2 RNCE - Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy]
3 LSHTM - London School of Hygiene and Tropical Medicine
4 CHU Trousseau [APHP]
5 AP-HP Hôpital universitaire Robert-Debré [Paris]
6 IHOPe - Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL]
7 Hôpital Jeanne de Flandres
8 Hôpital des Enfants
9 TIMONE - Hôpital de la Timone [CHU - APHM]
10 Hôpital Arnaud de Villeneuve
11 UM - Université de Montpellier
12 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
13 Hôpital Pellegrin
14 CHU Nantes - Centre hospitalier universitaire de Nantes
15 CNG - Centre National de Génotypage
Abstract : BACKGROUND: Previous studies on the putative role of allergy in the aetiology of childhood leukaemia have reported contradictory results. The present study aimed to analyse the relation between a medical history of asthma or eczema and childhood acute lymphoid leukaemia (ALL) in light of potential candidate gene-environment interactions. METHODS: Analyses were based on a subset of 434 cases of ALL and 442 controls successfully genotyped and of European ancestry children enrolled in a French population-based case-control study conducted in 2003-2004. Information about medical history was obtained during a standardized interview with the mothers. Candidate polymorphisms in genes of the Th2 cytokines IL4, IL10, IL13 and IL4-receptor, were genotyped or imputed. RESULTS: None of the variant alleles were directly associated with childhood acute lymphoid leukaemia. A medical history of asthma or eczema was reported more often in the control group (OR = 0.7 [0.5-1.0]). This association was mostly seen in the group of children not carrying the IL13-rs20541 variant allele (Interaction Odds Ratio IOR 1.9, p-interaction = 0.07) and in those carrying the IL10 triple variant haplotype (IOR 0.5, p-interaction = 0.04). No interaction was observed with the candidate polymorphisms in IL4 and IL4R. CONCLUSION: This study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia.
Keywords : Allergy Asthma Childhood leukaemia Cytokines Epidemiology Gene-environment interactions
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https://hal.umontpellier.fr/hal-02319684
Contributeur : Anthony Herrada <>
Soumis le : vendredi 18 octobre 2019 - 11:07:46
Dernière modification le : vendredi 27 mars 2020 - 02:39:57

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UNIV-MONTPELLIER | INRA | HCL | CEA | UNIV-PARIS5 | JACOB | UNIV-PARIS7 | USPC | CEA-DRF

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A. Bonaventure, L. Orsi, J. Rudant, S. Goujon-Bellec, G. Leverger, et al.. Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE). Cancer Epidemiology, Elsevier, 2018, 55, pp.96-103. ⟨10.1016/j.canep.2018.05.004⟩. ⟨hal-02319684⟩

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