Consciousness assessment by activated cerebral 18F-FDG PET complemented with the Wessex head injury matrix (WHIM) in patients with disorder of consciousness (DOC)

Abstract : Objective Cerebral 18F-FDG PET complements bedside examination with behavioural scales in patients with DOC enabling better functional categorization. We realized a resting PET, then another after motor/visual activation, in patients with DOC according to their clinical course. Material/patients and methods It is a retrospective mono central study in our acute inpatients rehabilitation unit between 2011 and 2014. Our group consists of 14 patients (whom 5 women) with DOC, 18–70 years old at moment of brain injury (6 severe TBI, 4 anoxia, 3 hemorrhagic and 1 ischemic major strokes). All had months after brain lesions (average delay 186 days), DOC assessment by the Wessex head injury matrix (WHIM), a basal resting state PET, followed by an activated one consisting on providing motor or visual stimulation during second PET. Distant WHIM was performed at least 6 months after (average 14.8 months). We defined 3 groups: (1) WHIM at [1–14], (2) WHIM at [15–29] and (3) WHIM at [30–58]. We analysed, by compared T test of each patient, metabolic increment between basal and activated PET-scan according to clinical course. Results All patients had initial significant increase of metabolism in the activated PET-scan compared with basal ones, but patterns were not always consistent with assigned task. But this significant activation (FWE [P < 0,005]) was particularly located in left occipital, parietal and temporal associative areas, among patients with further best clinical course. Discussion - conclusion All sever DOC had metabolic increase on activated PET-scan during first year post injury (average 6 months). Among patients with best clinical course we noticed that initial increased metabolism was located in left visual associative cortex and language/phonology treatment areas.
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https://hal.umontpellier.fr/hal-02295457
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Soumis le : mardi 24 septembre 2019 - 11:17:37
Dernière modification le : jeudi 26 septembre 2019 - 16:29:55

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Laurent Collombier, Vincent Boudousq, Marion Belorgeot, Francesa Ramella, Frédéric Pellas. Consciousness assessment by activated cerebral 18F-FDG PET complemented with the Wessex head injury matrix (WHIM) in patients with disorder of consciousness (DOC). Annals of Physical and Rehabilitation Medicine, Elsevier Masson, 2016, 59 (Supplement), pp.e152. ⟨10.1016/j.rehab.2016.07.338⟩. ⟨hal-02295457⟩

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