A histopathological classification system of Tyr::NRAS Q61K murine melanocytic lesions: A reproducible simplified classification

Abstract : Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic, revealed a very good agreement between observers. Should this new simplified classification be adopted, it would create a robust system of communication between researchers in the field of mouse melanoma models.
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https://hal.umontpellier.fr/hal-02292324
Contributeur : Anthony Herrada <>
Soumis le : jeudi 19 septembre 2019 - 16:21:33
Dernière modification le : mercredi 6 novembre 2019 - 18:20:07

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Pierre Sohier, Léa Legrand, Zackie Aktary, Christine Grill, Veronique Delmas, et al.. A histopathological classification system of Tyr::NRAS Q61K murine melanocytic lesions: A reproducible simplified classification. Pigment Cell & melanoma research, Blackwell Munksgaard, 2018, 31 (3), pp.423-431. ⟨10.1111/pcmr.12677⟩. ⟨hal-02292324⟩

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