Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.

Domaines

Médecine humaine et pathologie Cancer

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https://hal.umontpellier.fr/hal-02289349

Soumis le : lundi 16 septembre 2019-15:37:40

Dernière modification le : mercredi 20 mars 2024-17:10:15

Dates et versions

hal-02289349 , version 1 (16-09-2019)

Identifiants

HAL Id : hal-02289349 , version 1
DOI : 10.1002/cam4.1403
PUBMED : 29656586
PUBMEDCENTRAL : PMC5943428

Citer

Antoine Italiano, Nathan Touati, Saskia Litière, Françoise Collin, Philippe Pourquier, et al.. Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial. Cancer Medicine, 2018, 7 (5), pp.1575-1577. ⟨10.1002/cam4.1403⟩. ⟨hal-02289349⟩

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INSERM FNCLCC BERGONIE CGFL VALDAURELLE BS UNIV-MONTPELLIER IRCM

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