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Health Status and Quality of Life of Long-term Survivors of Childhood Acute Leukemia

Abstract : We evaluated the impact of central nervous system irradiation (CNSI) on long-term health status and quality of life (QoL) of childhood lymphoblastic leukemia survivors included in the French L.E.A. (Childhood and Adolescent Leukemia) multicentric cohort. QoL was self-reported in adults and assessed by parents in children and adolescents, using adapted questionnaires. From 2004 to 2009, 630 nongrafted patients were assessed after 11.8±6.3 years from diagnosis. Patients receiving CNSI (18.6%) or chemotherapy alone (81.4%) were compared. The risk of having long-term physical effects was increased with CNSI (odds ratio=3.3; 95% confidence interval, 1.8-5.9), especially regarding growth failure, second tumor, cataract, and overweight. QoL did not differ significantly according to the treatment received, despite a tendency toward lower scores with CNSI in children and adolescents (summary score 63.6±13.3 vs. 71.7±12.4, P=0.14). Compared with French norms, adult survivors had an impaired QoL, especially in mental domains (mental composite score 45.2±9.8 vs. 47.9±2.1, P<0.001). In pediatric survivors, QoL was not impaired and even tended to be higher than population norms (summary score 71.7±12.4 vs. 70.0±4.2, P=0.054), mainly in social and relational domains. In conclusion, QoL seems to be impaired by the trauma of a life-threatening illness in childhood, as well as by the treatment received.
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https://hal.umontpellier.fr/hal-02278882
Contributeur : Anthony Herrada <>
Soumis le : mercredi 4 septembre 2019 - 17:07:19
Dernière modification le : vendredi 15 mai 2020 - 12:22:07

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Joy Benadiba, Gérard Michel, Pascal Auquier, Pascal Chastagner, Justyna Kanold, et al.. Health Status and Quality of Life of Long-term Survivors of Childhood Acute Leukemia. Journal of Pediatric Hematology/Oncology, Lippincott, Williams & Wilkins, 2015, 37 (2), pp.109-116. ⟨10.1097/MPH.0000000000000209⟩. ⟨hal-02278882⟩

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