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Article Dans Une Revue Journal of Pediatric Hematology/Oncology Année : 2015

Health Status and Quality of Life of Long-term Survivors of Childhood Acute Leukemia

Joy Benadiba
  • Fonction : Auteur
Gérard Michel
  • Fonction : Auteur
Pascal Auquier
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  • PersonId : 860193
Pascal Chastagner
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  • PersonId : 759710
  • IdRef : 080522599
Justyna Kanold
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Marilyne Poirée
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Dominique Plantaz
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Laetitia Padovani
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Julie Berbis
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Vincent Barlogis
Audrey Contet
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Hervé Chambost
  • Fonction : Auteur


We evaluated the impact of central nervous system irradiation (CNSI) on long-term health status and quality of life (QoL) of childhood lymphoblastic leukemia survivors included in the French L.E.A. (Childhood and Adolescent Leukemia) multicentric cohort. QoL was self-reported in adults and assessed by parents in children and adolescents, using adapted questionnaires. From 2004 to 2009, 630 nongrafted patients were assessed after 11.8±6.3 years from diagnosis. Patients receiving CNSI (18.6%) or chemotherapy alone (81.4%) were compared. The risk of having long-term physical effects was increased with CNSI (odds ratio=3.3; 95% confidence interval, 1.8-5.9), especially regarding growth failure, second tumor, cataract, and overweight. QoL did not differ significantly according to the treatment received, despite a tendency toward lower scores with CNSI in children and adolescents (summary score 63.6±13.3 vs. 71.7±12.4, P=0.14). Compared with French norms, adult survivors had an impaired QoL, especially in mental domains (mental composite score 45.2±9.8 vs. 47.9±2.1, P<0.001). In pediatric survivors, QoL was not impaired and even tended to be higher than population norms (summary score 71.7±12.4 vs. 70.0±4.2, P=0.054), mainly in social and relational domains. In conclusion, QoL seems to be impaired by the trauma of a life-threatening illness in childhood, as well as by the treatment received.
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Dates et versions

hal-02278882 , version 1 (04-09-2019)



Joy Benadiba, Gérard Michel, Pascal Auquier, Pascal Chastagner, Justyna Kanold, et al.. Health Status and Quality of Life of Long-term Survivors of Childhood Acute Leukemia. Journal of Pediatric Hematology/Oncology, 2015, 37 (2), pp.109-116. ⟨10.1097/MPH.0000000000000209⟩. ⟨hal-02278882⟩
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