Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group - Université de Montpellier
Article Dans Une Revue HPB Année : 2015

Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group

Jean-Marc Régimbeau
David Fuks
  • Fonction : Auteur
Denis Chatelain
  • Fonction : Auteur
  • PersonId : 1149906
  • IdRef : 080482635
Momar Diouf
Artigas Raventos
  • Fonction : Auteur
Jean-Francois Gigot
  • Fonction : Auteur
Gérard Pascal
  • Fonction : Auteur
  • PersonId : 921470
Alexis Laurent
Jean-Yves Mabrut
  • Fonction : Auteur
  • PersonId : 907740
Jean-Robert Delpero
Gennaro Nuzzo
  • Fonction : Auteur
Michel Scotté
  • Fonction : Auteur
  • PersonId : 944264
Olivier Farges
  • Fonction : Auteur
  • PersonId : 1236843
  • IdRef : 035634693

Résumé

INTRODUCTION: As mortality and morbidity after a curative resection remains high, it is essential to identify pre-operative factors associated with an early death after a major resection. METHODS: Between 1998 and 2008, we selected a population of 331 patients having undergone a major hepatectomy including segment I with a lymphadenectomy and a common bile duct resection for a proven hilar cholangiocarcinoma in 21 tertiary centres. The study's objective was to identify pre-operative predictors of early death (<12 months) after a resection. RESULTS: The study cohort consisted of 221 men and 110 women, with a median age of 61 years (range: 24-85). The post-operative mortality and morbidity rates were 8.2% and 61%, respectively. The 1-, 3- and 5-year overall survival rates were 85%, 64% and 53%, respectively. The median tumour size was 23 mm on pathology, ranging from 8 to 40. A tumour size >30 mm [odds ratio (OR) 2.471 (95% confidence interval (CI) 1.136-7.339), P = 0.001] and major post-operative complication [OR 3.369 (95% CI 1.038-10.938), P = 0.004] were independently associated with death <12 months in a multivariate analysis. CONCLUSION: The present analysis of a series of 331 patients with hilar cholangiocarcinoma showed that tumour size >30 mm was independently associated with death <12 months.

Dates et versions

hal-02278840 , version 1 (04-09-2019)

Identifiants

Citer

Jean-Marc Régimbeau, David Fuks, Patrick Pessaux, Philippe Bachellier, Denis Chatelain, et al.. Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group. HPB, 2015, 17 (1), pp.79-86. ⟨10.1111/hpb.12296⟩. ⟨hal-02278840⟩
69 Consultations
0 Téléchargements

Altmetric

Partager

More