Adult sinonasal soft tissue sarcoma: Analysis of 48 cases from the French Sarcoma Group database

Abstract : OBJECTIVE: The aim of this study was to determine the frequency of primary sinonasal adult sarcoma, identify histological subtypes, and analyze prognostic factors. STUDY DESIGN: Retrospective review. METHOD: Forty-eight adult sinonasal sarcomas included in the French Sarcoma Group database (Conticabase) were reviewed. RESULTS: The most frequent tumor types were alveolar rhabdomyosarcoma (33.3%), embryonal rhabdomyosarcoma (14,6%), unclassified sarcoma (14.6%), and leiomyosarcoma (12.5%). All round cell tumors were rhabdomyosarcomas. The 5-year overall survival (OS), metastasis-free survival (MFS), and local recurrence-free survival (LRFS) rates were 62.3%, 73%, and 88.8%, respectively. Histotype was a prognostic factor for OS, MFS, and LRFS, with the worst prognosis associated with rhabdomyosarcomas, regardless of the subtype. The tumor grade influenced the OS and MFS. Surgery was a predictive factor for a complete response. CONCLUSIONS: These results suggest that sinonasal tract should be considered as an unfavorable site for rhabdomyosarcoma. Moreover, surgery should always be considered in treatment.
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https://hal.umontpellier.fr/hal-02277113
Contributeur : Anthony Herrada <>
Soumis le : mardi 3 septembre 2019 - 13:46:41
Dernière modification le : jeudi 19 septembre 2019 - 10:40:29

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Vanessa Szablewski, Agnès Neuville, Philippe Terrier, Marick Laé, Roxane Schaub, et al.. Adult sinonasal soft tissue sarcoma: Analysis of 48 cases from the French Sarcoma Group database. Laryngoscope, Wiley, 2015, 125 (3), pp.615-623. ⟨10.1002/lary.24910⟩. ⟨hal-02277113⟩

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