Conductrices d’hémophilie : expérience d’un CHRU en France

Abstract : OBJECTIVES: To report the management of carriers of haemophilia in a French university hospital and assess different issues of these patients. PATIENTS AND METHODS: Retrospective study of the carriers of haemophilia who consulted at the university hospital of Montpellier, France, between 1995 and 2011. Information were obtained from medical records and from a questionnaire sent to carriers. We recorded data about biological characteristics, bleeding tendency and management of pregnancies. RESULTS: Sixty-four carriers of haemophilia A or B were included. Their median FVIII or FIX level was 52 % (range, 15-137 %). Menstrual bleeding lasted more than 7 days in 31 % of carriers. A total of 142 pregnancies started in 54 carriers, and 101 resulted in live births with 26 boys with haemophilia. Sixty-two prenatal diagnoses carried out, 15 have terminated their pregnancy because of a hemophiliac male fetus. Seventy-six percent of deliveries were vaginal delivery and 49 % took place in a level-3 maternity. There were 10.8 % and 8.5 % primary and secondary post-partum hemorrhage, respectively. CONCLUSION: The risk of bleeding among carriers of haemophilia is associated with their antihemophilic factor level. To improve the management of carriers, a multidisciplinary and standardized medical record, with a specific questionnaire to evaluate bleedings, could be considered. A regional register that lists all carriers, regardless of their antihemophilic factor level, would also be useful.
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https://hal.umontpellier.fr/hal-02273687
Contributeur : Anthony Herrada <>
Soumis le : jeudi 29 août 2019 - 10:39:37
Dernière modification le : jeudi 29 août 2019 - 10:39:38

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P. Sauguet, P. Aguilar-Martinez, P. Boulot, J.-B. Escudié, J.-F. Schved, et al.. Conductrices d’hémophilie : expérience d’un CHRU en France. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2015, 44 (6), pp.565-576. ⟨10.1016/j.jgyn.2014.08.009⟩. ⟨hal-02273687⟩

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