Incidence and risk factors for cataract after haematopoietic stem cell transplantation for childhood leukaemia: an LEA study - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue British Journal of Haematology Année : 2015

Incidence and risk factors for cataract after haematopoietic stem cell transplantation for childhood leukaemia: an LEA study

Pascal Chastagner
  • Fonction : Auteur
  • PersonId : 759710
  • IdRef : 080522599

Résumé

Cataract was prospectively assessed by serial slip lamp tests in 271 patients included in the Leucémie Enfants Adolescents (LEA) programme, the French cohort of childhood leukaemia survivors. All had received haematopoietic stem cell transplantation (HSCT) after total body irradiation (TBI, n = 201) or busulfan-based (n = 70) myeloablative conditioning regimen. TBI was fractionated in all but six patients. The mean duration of follow-up from HSCT was 10·3 years. Cataract was observed in 113/271 patients (41·7%); 9/113 (8·1%) needed surgery. Cumulative incidence after TBI increased over time from 30% at 5 years to 70·8% and 78% at 15 and 20 years, respectively, without any plateau thereafter. The 15-year cumulative incidence was 12·5% in the Busulfan group. A higher cumulative steroid dose appeared to be a cofactor of TBI for cataract risk, in both univariate and multivariate Cox analysis. In the multivariate analysis, cataract had an impact in two quality of life domains: 'the role limitation due to physical problems' and 'the role limitation due to emotional problems'. These data suggest that with increasing follow-up, nearly all patients who receive TBI, even when fractionated, will suffer from cataract that can impact on their quality of life and that high cumulative steroid dose is a cofactor.

Domaines

Hématologie
Fichier non déposé

Dates et versions

hal-02272010 , version 1 (27-08-2019)

Identifiants

Citer

Meryl Horwitz, Pascal Auquier, Vincent Barlogis, Audrey Contet, Maryline Poiree, et al.. Incidence and risk factors for cataract after haematopoietic stem cell transplantation for childhood leukaemia: an LEA study. British Journal of Haematology, 2015, 168 (4), pp.518-525. ⟨10.1111/bjh.13148⟩. ⟨hal-02272010⟩
29 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More