Unexpected co-detection of promastigote and amastigote Leishmania forms in a human cutaneous lesion: implications for leishmaniasis physiopathology and treatment

Abstract : Cutaneous leishmaniasis pathogenicity depends on the survival and replication of the parasitic protozoa in the form of non-motile amastigotes inside macrophages. Here, we report the unprecedented observation of both Leishmania major amastigote and promastigote forms (the latter is normally detected only in the mid gut of the insect vector or in vitro culture) in a cutaneous lesion of a 6-year-old boy. This finding suggests that modifications of the skin lesion environment, such as maceration and changes in pH or temperature, could promote the in situ transformation of Leishmania amastigotes into promastigotes. This observation raises questions about the physiopathology of cutaneous leishmaniasis and the influence of micro-environmental changes on the efficiency of topical treatments.
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https://hal.umontpellier.fr/hal-02271947
Contributeur : Anthony Herrada <>
Soumis le : mardi 27 août 2019 - 13:23:53
Dernière modification le : mercredi 28 août 2019 - 01:18:40

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Najoua Haouas, Latifa Remadi, Dhekra Chaara, Najla Chargui, Radhia Dabghi, et al.. Unexpected co-detection of promastigote and amastigote Leishmania forms in a human cutaneous lesion: implications for leishmaniasis physiopathology and treatment. Diagnostic Microbiology and Infectious Disease, Elsevier, 2015, 81 (1), pp.18-20. ⟨10.1016/j.diagmicrobio.2014.09.014⟩. ⟨hal-02271947⟩

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