Congress organisation: Public Health Research Institute (IReSP), Alliance for life sciences and health (Aviesan), National Research Agency on AIDS and viral hepatitis (ANRS), National Cancer Institute (INCa). Integrated and Comprehensive Health Interventions (ICHIs), also called Non Pharmacological Interventions (NPIs), have become essential solutions to improve health, quality of life and, often, life expectancy. Recent studies have also highlighted the positive social and economic impact. "ICHIs are non-invasive methods of care (programs, products or services) whose efficacy in improving the health and quality of life of human beings has been proven. Their effects on health and quality of life markers are observable (with measured risks and benefits beyond mere user opinions) and can be linked to identify biological and/or psychological processes. They can also have a positive impact on health behaviours and socio-economic indicators” (CEPS Platform, 2016). Many authors (e.g., Ioannidis, 2015) and health authorities argue that what has been brought forth is merely proof of concept (e.g., French Health Authority, 2011). They note the lack of a consensus paradigm of validation and surveillance, such as the standards in drug development. They highlight the methodology problems due to rapid obsolescence of ICHI using a digital solution (e.g., Mobile Apps). As a result, policy makers and health decision-makers remain skeptical of the impact of ICHIs. These key players are encouraging innovators to come forward with additional evidence for the efficacy and the cost/effectiveness of ICHIs in order to improve their visibility, and, ultimately, to garner more substantive private and public financial support for them. ICHIs need to be compared and optimized, as well as targeted to the right health problem at the right time. The first step will be to develop a collaborative top-down strategy to identify and classify these health interventions. The communication presents our strategy supported by French State, Occitanie Region, and Montpellier Metropole. The CEPS Platform: An European Academic Platform Dedicated to Research Methodology For NPIs / Universities of Montpellier, France / www.cepsplatform.eu