Prospect of Thiazole‐based γ‐Peptide Foldamers in Enamine Catalysis: Exploration of the Nitro‐Michael Addition - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2019

Prospect of Thiazole‐based γ‐Peptide Foldamers in Enamine Catalysis: Exploration of the Nitro‐Michael Addition

Résumé

As three‐dimensional folding is prerequisite to biopolymer activity, complex functions may also be achieved through foldamer science. Because of the diversity of sizes, shapes and folding available with synthetic monomers, foldamer frameworks enable a numerous opportunities for designing new generations of catalysts. We herein demonstrate that heterocyclic γ‐peptide scaffolds represent a versatile platform for enamine catalysis. One central feature was to determine how the catalytic activity and the transfer of chiral information might be under the control of the conformational behaviours of the oligomer.

Domaines

Chimie Catalyse
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Dates et versions

hal-02167326 , version 1 (27-06-2019)

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Citer

Julie Aguesseau‐kondrotas, Matthieu Simon, Baptiste Legrand, Jean‐louis Bantigniès, Young Kee Kang, et al.. Prospect of Thiazole‐based γ‐Peptide Foldamers in Enamine Catalysis: Exploration of the Nitro‐Michael Addition. Chemistry - A European Journal, 2019, 25 (30), pp.7396-7401. ⟨10.1002/chem.201901221⟩. ⟨hal-02167326⟩
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