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Communication dans un congrès

The marine mussel Mytilus galloprovincialis bioconcentrate and metabolize antidepressant pharmaceutical venlafaxine

Abstract : A significant investment in research has been conducted to define exposures and potential hazards of pharmaceuticals in freshwater and terrestrial ecosystems. In contrast, comparatively few empirical studies have been conducted for pharmaceuticals that are likely to enter coastal and marine ecosystems[1,2]. The antidepressant venlafaxine (VLF) and some of its metabolites were recently found in mussels caged in a coastal site receiving treated wastewater[3]. In those marine organisms, very scarce data is available on the accumulation and/or metabolisation of pharmaceuticals. Consequently, it appears hazardous to conclude on the origin of those metabolites in mussels, which could include a bioaccumulation through direct exposure as well as a metabolism of VLF in mussels. The aim of the present work was to quantify the accumulation of VLF in the marine mussel Mytilus galloprovincialis and to evaluate the possible metabolism in laboratory controlled experiments. The accumulation of VLF was evaluated in the whole mussel tissues after 1, 3 and 7 days of semi-static exposure by water (10µg L-1day-1) followed by 1, 3 and 7 days of depuration. Under those conditions, VLF attained an average tissue concentration of (n=3) 2146.3 ± 156.0 ng g-1 dry weight (d.w.) in seven days. The kinetic bioconcentration factor (BCF) was 265 ± 19 L kg-1 d.w. Seven days of depuration allowed a decrease of tissue concentration to 21 ± 1.0 ng g-1 d.w. Four VLF metabolites were quantified in mussel tissues and excreted in water. The kinetics of those metabolites in water confirmed the metabolism of VLF by mussels. Complementary experiment conducted at 1, 10 and 100 µL L-1 nominal concentration clearly confirmed that M. galloprovincialis metabolize VLF, with the quantification of studied metabolites excepted the NNO-VLF. These results gave a first approach on the ability of mussel to metabolize pharmaceuticals. Together with bioaccumulation information, this study provided a first approach on the pharmacokinetics of a pharmaceutical in a wild marine species, underlining the need of further experiments to better understand how venlafaxine modulate the receptors in mussels and how exposure to this antidepressant affects physiological functions of invertebrates.
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Contributeur : Pascale Roussel <>
Soumis le : vendredi 10 mai 2019 - 17:33:26
Dernière modification le : vendredi 15 mai 2020 - 12:22:07


  • HAL Id : hal-02125979, version 1



Elena Gomez, C. Boillot, M. Martinez Bueno, Dominique Munaron, Mathieu Olivier, et al.. The marine mussel Mytilus galloprovincialis bioconcentrate and metabolize antidepressant pharmaceutical venlafaxine. 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe), May 2016, Nantes, France. ⟨hal-02125979⟩



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