Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical characterization and stability study

Abstract : The phase behavior of the four-component Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex fluids were identified. Non usual W/O microemulsion (L2) as well as hexagonal (H2) liquid-crystal phases were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this complex system.
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https://hal.umontpellier.fr/hal-02117028
Contributeur : Olivier Diat <>
Soumis le : mercredi 1 mai 2019 - 23:01:10
Dernière modification le : mardi 28 mai 2019 - 17:04:08

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Abdelkader Mouri, Olivier Diat, Abdeslam El Ghzaoui, Isabelle Ly, Christophe Dorandeu, et al.. Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical characterization and stability study. Journal of Colloid and Interface Science, Elsevier, 2015, 457, pp.152-161. ⟨10.1016/j.jcis.2015.06.010⟩. ⟨hal-02117028⟩

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