The hydrometeorological components of five Dudh Koshi River sub-basins on the Nepalese side of the Mount Everest have been monitored during four hydrological years (2013-2017), with altitudes ranging from 2000 m to Everest top, areas between 4.65 and 1207 km², and proportions of glaciated areas between nil and 45%. This data set is completed with glacier mass balance observations. The analysis of the observed data and the resulting water balances show large uncertainties of different types: aleatory, epistemic or semantic, following the classification proposed by Beven (2016). The discussion is illustrated using results from two modeling approaches, physical (ISBA, Noilhan and Planton, 1996) and conceptual (J2000, Krause, 2001), as well as large scale glacier mass balances obtained by the way of a recent remote sensing processing method.