Class C G protein-coupled receptors: reviving old couples with new partners

Abstract : G protein-coupled receptors (GPCRs) are key players in cell communication and are encoded by the largest family in our genome. As such, GPCRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPCRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPCRs, the class F includes the frizzled receptors, and the class C includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. Class C receptors are far more complex than other GPCRs, being mandatory dimers, with each subunit being composed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class C GPCRs, and how this brings information for many other GPCRs.
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Soumis le : mardi 19 mars 2019 - 16:26:25
Dernière modification le : mardi 28 mai 2019 - 14:12:02

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Thor Møller, David Moreno-Delgado, Jean-Philippe Pin, Julie Kniazeff. Class C G protein-coupled receptors: reviving old couples with new partners. Biochemistry and Biophysics Reports, 2017, 3 (4-6), pp.57-63. ⟨10.1007/s41048-017-0036-9⟩. ⟨hal-02073162⟩



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