β-Carboline Alkaloids from Galianthe ramosa Inhibit Malate Synthase from Paracoccidioides spp.

Abstract : As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.
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https://hal.umontpellier.fr/hal-02066260
Contributeur : Yannick Brohard <>
Soumis le : mercredi 13 mars 2019 - 11:52:20
Dernière modification le : vendredi 29 mars 2019 - 09:10:41

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  • HAL Id : hal-02066260, version 1

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Carla Cecília de Freitas, Lucilia Kato, Cecília M. A. de Oliveira, Luiz H. K. Queiroz Jr., Mábio J. Santana, et al.. β-Carboline Alkaloids from Galianthe ramosa Inhibit Malate Synthase from Paracoccidioides spp.. Planta Medica, Georg Thieme Verlag, 2014, 80 (18), pp.1746-1752. ⟨hal-02066260⟩

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