Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations

Abstract : Malarial infections have long been recognized as a driver of human evolution, as demonstrated by the influence of Plasmodium falciparum on sickle-cell anemia persistence. Duffy-negativity is another blood disorder thought to have been selected because it confers nearly complete resistance against Plasmodium vivax infection. Recent evidence suggests that the benefits of being Duffy-negative cannot be expected to play a strong selective pressure on humans, whereas its costs cannot be considered as negligible. Here, we suggest that the cross-talk between P. falciparum and P. vivax in coinfected children could represent the most parsimonious explanation of the frequency of Duffy-negativity. We discuss how this new hypothesis could be tested and call for a reconsideration of the evolution of the Duffy-negative group.
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https://hal.umontpellier.fr/hal-02013924
Contributeur : Philip Agnew <>
Soumis le : lundi 11 février 2019 - 12:07:53
Dernière modification le : vendredi 9 août 2019 - 15:18:06

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Benjamin Roche, Virginie Rougeron, Lluís Quintana-Murci, François Renaud, Jessica Lee Abbate, et al.. Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations. Trends in Parasitology, Elsevier, 2017, 33 (1), pp.21-29. ⟨10.1016/j.pt.2016.09.010⟩. ⟨hal-02013924⟩

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