African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes

Abstract : ZIKA virus (ZIKV) is a newly emerging arbovirus. Since its discovery 60years ago in Uganda, it has spread throughout the Pacific, Latin America and the Caribbean, emphasizing the capacity of ZIKV to spread to non-endemic regions worldwide. Although infection with ZIKV often leads to mild disease, its recent emergence in the Americas has coincided with an increase in adults developing Guillain-Barré syndrome and neurological complications in new-borns, such as congenital microcephaly. Many questions remain unanswered regarding the complications caused by different primary isolates of ZIKV. Here, we report the permissiveness of primary human astrocytes for two clinically relevant, Asian and African ZIKV strains and show that both isolates strongly induce antiviral immune responses in these cells albeit with markedly different kinetics. This study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.umontpellier.fr/hal-02010991
Contributeur : Philip Agnew <>
Soumis le : jeudi 7 février 2019 - 15:44:40
Dernière modification le : mercredi 29 mai 2019 - 10:56:23

Identifiants

Citation

Rodolphe Hamel, Pauline Ferraris, Sineewanlaya Wichit, Fode Diop, Loïc Talignani, et al.. African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes. Infection, Genetics and Evolution, Elsevier, 2017, 49, pp.134-137. ⟨10.1016/j.meegid.2017.01.015⟩. ⟨hal-02010991⟩

Partager

Métriques

Consultations de la notice

39