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Chapitre D'ouvrage Année : 2018

Targeting Glucocorticoid Receptors: A New Avenue for Alzheimer’s Disease Therapy

Résumé

Mostly Alzheimer’s disease (AD) cases are sporadic, with no clear intrinsic triggering mechanisms but with identified risk factors. Environmental stress factors are thought to account for approximately 25–40% of the risk to develop AD. Elevated levels of glucocorticoids and irregulated hypothalamic-pituitary-adrenal (HPA) axis (or stress axis) are consistently observed in patients of AD. In rodent experimental models of AD, a dysregulation of HPA axis is also observed, and either stress or direct treatment with glucocorticoids in these models worsens hallmarks of AD at the molecular, histological, and behavioral levels.
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Dates et versions

hal-02007848 , version 1 (05-02-2019)

Identifiants

  • HAL Id : hal-02007848 , version 1

Citer

Geoffrey Canet, Nathalie Chevallier, Veronique Perrier, Catherine Desrumaux, Laurent Givalois. Targeting Glucocorticoid Receptors: A New Avenue for Alzheimer’s Disease Therapy. Sarika Singh, Neeraj Joshi. Pathology, Prevention and Therapeutics of Neurodegenerative Disease, Springer Singapore, pp.173-183, 2018, 978-981-13-0943-4. ⟨hal-02007848⟩
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