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Article Dans Une Revue Future Neurology Année : 2018

Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology

Résumé

Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer's disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced pluripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.

Dates et versions

hal-02007783 , version 1 (05-02-2019)

Identifiants

Citer

Lisa Mohamet, Vicky Jones, G. Dayanithi, Alexei Verkhratsky. Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology. Future Neurology, 2018, 13 (2), pp.87-99. ⟨10.2217/fnl-2017-0029⟩. ⟨hal-02007783⟩
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