Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology

Abstract : Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer's disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced pluripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.
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https://hal.umontpellier.fr/hal-02007783
Contributeur : Anthony Herrada <>
Soumis le : mardi 5 février 2019 - 13:55:21
Dernière modification le : jeudi 30 mai 2019 - 01:42:33

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  • HAL Id : hal-02007783, version 1

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Lisa Mohamet, Vicky Jones, Govindan Dayanithi, Alexei Verkhratsky. Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology. Future Neurology, Future Medicine, 2018, 13 (2), pp.87-99. ⟨hal-02007783⟩

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