Comparing Treatment Effect Measurements in Narcolepsy: The Sustained Attention to Response Task, Epworth Sleepiness Scale and Maintenance of Wakefulness Test - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue SLEEP Année : 2015

Comparing Treatment Effect Measurements in Narcolepsy: The Sustained Attention to Response Task, Epworth Sleepiness Scale and Maintenance of Wakefulness Test

Astrid van Der Heide
  • Fonction : Auteur
Mojca van Schie
  • Fonction : Auteur
Gert Jan Lammers
  • Fonction : Auteur
Geert Mayer
Claudio Bassetti
Claire-Li Ding
  • Fonction : Auteur
Philippe Lehert
  • Fonction : Auteur
J Gert van Dijk
  • Fonction : Auteur
Mojca K.M. van Schie
  • Fonction : Auteur
J. Gert van Dijk
  • Fonction : Auteur

Résumé

STUDY OBJECTIVES: To validate the Sustained Attention to Response Task (SART) as a treatment effect measure in narcolepsy, and to compare the SART with the Maintenance of Wakefulness Test (MWT) and the Epworth Sleepiness Scale (ESS). DESIGN: Validation of treatment effect measurements within a randomized controlled trial (RCT). PATIENTS: Ninety-five patients with narcolepsy with or without cataplexy. INTERVENTIONS: The RCT comprised a double-blind, parallel-group, multicenter trial comparing the effects of 8-w treatments with pitolisant (BF2.649), modafinil, or placebo (NCT01067222). MWT, ESS, and SART were administered at baseline and after an 8-w treatment period. The severity of excessive daytime sleepiness and cataplexy was also assessed using the Clinical Global Impression scale (CGI-C). MEASUREMENTS AND RESULTS: The SART, MWT, and ESS all had good reliability, obtained for the SART and MWT using two to three sessions in 1 day. The ability to distinguish responders from nonresponders, classified using the CGI-C score, was high for all measures, with a high performance for the SART (r = 0.61) and the ESS (r = 0.54). CONCLUSIONS: The Sustained Attention to Response Task is a valid and easy-to-administer measure to assess treatment effects in narcolepsy, enhanced by combining it with the Epworth Sleepiness Scale.

Dates et versions

hal-02005749 , version 1 (04-02-2019)

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Astrid van Der Heide, Mojca van Schie, Gert Jan Lammers, Yves Dauvilliers, Isabelle Arnulf, et al.. Comparing Treatment Effect Measurements in Narcolepsy: The Sustained Attention to Response Task, Epworth Sleepiness Scale and Maintenance of Wakefulness Test. SLEEP, 2015, 38 (7), pp.1051-1058. ⟨10.5665/sleep.4810⟩. ⟨hal-02005749⟩
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