Modalités pratiques de traitement des kératoses actiniques par photothérapie dynamique topique en lumière du jour avec l’aminolévulinate de méthyle - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Annales de Dermatologie et de Vénéréologie Année : 2016

[Procedure for daylight methyl aminolevulinate photodynamic therapy to treat actinic keratoses].

Modalités pratiques de traitement des kératoses actiniques par photothérapie dynamique topique en lumière du jour avec l’aminolévulinate de méthyle

Résumé

Actinic keratosis (AK), also known as solar keratosis or pre-cancerous keratosis, is frequently observed in areas of skin exposed to sunlight, particularly in light-skinned patients. In France, photodynamic therapy using red light (conventional PDT) and methylamino 5-levulinate (MAL) is indicated in the treatment of thin or non-hyperkeratotic and non-pigmented multiple AK lesions or large zones covered with AK lesions. It is well-known for its efficacy but also for its side effects, especially pain during illumination, which can limit its use. An alternative to PDT using natural daylight has recently been proposed to treat actinic keratosis lesions, and results in greater flexibility as well as significant reduction in pain. The lesions are prepared as for conventional PDT, with MAL cream being applied by the physician or the patient, after which they are exposed to natural daylight for 2hours. The lesions are then gently cleansed and protected from natural light for 24hours. This paper seeks to provide a precise description of the daylight PDT procedure for the treatment of AK.
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Dates et versions

hal-01989234 , version 1 (22-01-2019)

Identifiants

Citer

Christian Girard, H. Adamski, N. Basset-Séguin, P. Beaulieu, B. Dreno, et al.. Modalités pratiques de traitement des kératoses actiniques par photothérapie dynamique topique en lumière du jour avec l’aminolévulinate de méthyle. Annales de Dermatologie et de Vénéréologie, 2016, 143 (4), pp.257-263. ⟨10.1016/j.annder.2016.02.016⟩. ⟨hal-01989234⟩
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