In vitro biocompatibility evaluation of bioresorbable copolymers prepared from l -lactide, 1, 3-trimethylene carbonate, and glycolide for cardiovascular applications - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Journal of Biomaterials Science, Polymer Edition Année : 2015

In vitro biocompatibility evaluation of bioresorbable copolymers prepared from l -lactide, 1, 3-trimethylene carbonate, and glycolide for cardiovascular applications

Jianting Dong
  • Fonction : Auteur
Zhongyong Fan
  • Fonction : Auteur
Yourong Duan
  • Fonction : Auteur
S.M. Li

Résumé

PLLA-TMC-GA terpolymer was prepared by ring-opening polymerization of l-lactide, 1, 3-trimethylene carbonate (TMC), and glycolide (GA). The biocompatibility of terpolymer was evaluated in comparison with PLLA and PLLA-TMC with the aim of assessing their potential in the development of bioresorbable cardiovascular stents. Various aspects of in vitro biocompatibility were considered, including MTT assay, hemolytic test, dynamic clotting time, platelet adhesion, platelet activation, protein adsorption, plasma recalcification time and release of cytokines. The results revealed that the terpolymer presents good cytocompatibility and hemocompatibility. Moreover, no significant increase in the release of cytokines was detected. It is thus concluded that these polymers, in particular PLLA-TMC-GA terpolymer present good biocompatibility for cardiovascular
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Dates et versions

hal-01985595 , version 1 (18-01-2019)

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Citer

Xin Shen, Feng Su, Jianting Dong, Zhongyong Fan, Yourong Duan, et al.. In vitro biocompatibility evaluation of bioresorbable copolymers prepared from l -lactide, 1, 3-trimethylene carbonate, and glycolide for cardiovascular applications. Journal of Biomaterials Science, Polymer Edition, 2015, 26 (8), pp.497-514. ⟨10.1080/09205063.2015.1030992⟩. ⟨hal-01985595⟩
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